Chiral ionic Br?nsted acid–achiral Br?nsted base synergistic catalysis for asymmetric sulfa-Michael addition to nitroolefins?

Chemical Science Pub Date: 2012-07-06 DOI: 10.1039/C2SC20698F

Abstract

A highly enantioselective sulfa-Michael addition to aromatic and aliphatic nitroolefins is achieved under the synergistic catalysis of chiral, ionic Br?nsted acid homo-1b·HBArF and 2,6-lutidine. The potential utility of this new method is clearly demonstrated by its application to the syntheses of a novel, optically active taurine derivative and β-sultam.

Graphical abstract: Chiral ionic Br?nsted acid–achiral Br?nsted base synergistic catalysis for asymmetric sulfa-Michael addition to nitroolefins
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