Cascade reaction for the construction of CF3 containing tetrasubstituted furan ring?
RSC Advances Pub Date: 2016-10-27 DOI: 10.1039/C6RA19782E
Abstract
Activated olefins are well known nucleophiles, but proton abstraction from the substituted α-methyl group in nitroolefin is rare. We report the first DBU-catalysed one-pot reaction of TFMK and activated nitroolefin followed by intramolecular cyclization reaction, to construct stereogenic center containing a furan core with CF3 in excellent yields (up to >95%).
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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