Br?nsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition?
Organic & Biomolecular Chemistry Pub Date: 2019-11-15 DOI: 10.1039/C9OB02379H
Abstract
A cascade reaction of 3-hydroxy-2-phenylisoindolin-1-one and cyclopropyl ketone has been developed via a Br?nsted acid-promoted ring-opening/intramolecular cross-cycloaddition/[4 + 2]-cycloaddition process. The developed methodology provides straightforward access to pentacyclic isoindolin-1-one derivatives under simple reaction conditions.
![Graphical abstract: Br?nsted acid mediated intramolecular cyclopropane ring expansion/[4 + 2]-cycloaddition](http://scimg.chem960.com/usr/1/C9OB02379H.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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