Serendipitous Synthesis of N-Tetrachlorophthaloyldehydroalanine Methyl Ester, a Michael Acceptor which is a Potential Precursor of γ-Carboxyglutamic Acid

Journal of Chemical Research, Synopses Pub Date: DOI: 10.1039/A806463F

Abstract

An attempt to synthesise a new protected serine derivative led to the isolation of N-tetrachlorophthaloyldehydroalanine methyl ester, which underwent Michael addition of dialkyl malonates to form γ-carboxyglutamic acid derivatives.

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