A catalyst free, multicomponent-tandem, facile synthesis of pyrido[2,3-d]pyrimidines using glycerol as a recyclable promoting medium?
New Journal of Chemistry Pub Date: 2015-10-27 DOI: 10.1039/C5NJ01938A
Abstract
A clean and efficient, multicomponent-tandem strategy for the synthesis of pyrido[2,3-d]pyrimidines is reported in glycerol, a biodegradable and reusable promoting medium. The advantages of the present methodology includes a one-pot catalyst free environmentally friendly approach, 100% atom economy, cost effectiveness, broad substrate scope, operational simplicity, short reaction times, easy workup procedure and high yields.
![Graphical abstract: A catalyst free, multicomponent-tandem, facile synthesis of pyrido[2,3-d]pyrimidines using glycerol as a recyclable promoting medium](http://scimg.chem960.com/usr/1/C5NJ01938A.jpg)
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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