Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds

RSC Advances Pub Date: 2023-06-20 DOI: 10.1039/D2RA07412E

Abstract

C–N cross-coupling bond formation reactions have become valuable approaches to synthesizing anilines and their derivatives, known as important chemical compounds. Recent developments in this field have focused on versatile catalysts, simple operation methods, and green reaction conditions. This review article presents an overview of C–N cross-coupling reactions in pharmaceutical compound synthesis reports. Selected examples of N-arylation reactions of various nitrogen-based compounds and aryl halides are defined for preparing pharmaceutical molecules.

Graphical abstract: Applications of palladium-catalyzed C–N cross-coupling reactions in pharmaceutical compounds
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