HFIP-mediated three-component imidization of electron-rich arenes with in situ formed spiroindolenines for facile construction of 2-arylspiroindolenines?
Organic Chemistry Frontiers Pub Date: 2022-02-14 DOI: 10.1039/D1QO01862K
Abstract
The three-component reaction of o-aminobenzaldehydes with 5-hydroxyindole and electron-rich arenes has been achieved through HFIP-mediated cascade hydride transfer/dearomative cyclization/CDC-type imidization at room temperature under air, providing a variety of 2-arylspiroindolenines carrying diverse functional groups with moderate to good yields. The derivatizations of the products also were conducted to enhance the synthetic practicality of this protocol.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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