An expedient, efficient and solvent-free synthesis of T3P?-mediated amidation of benzhydrols with poorly reactive N-nucleophiles under MW irradiation?
New Journal of Chemistry Pub Date: 2022-01-26 DOI: 10.1039/D1NJ04502D
Abstract
An expedient, efficient, economical, environmentally benign, and solvent free amidation protocol of benzhydrols with less reactive nitrogen nucleophiles assisted by propylphosphonic anhydride (T3P?) under microwave irradiation has been developed. The methodology has been deployed for a wide range of heterocycles and electron-withdrawing & electron-donating groups. The protocol resulted in good to excellent yields under the given conditions (26 examples, 68–93% yield).
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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