Ru(ii)-catalysed oxidative (4 + 2) annulation of chromene and coumarin carboxylic acids with alkynes/propargylic alcohols: isolation of Ru(0) complexes?
Organic & Biomolecular Chemistry Pub Date: 2022-12-09 DOI: 10.1039/D2OB01890J
Abstract
Ru(II)-catalysed oxidative (4 + 2) annulation of chromene and coumarin-3-carboxylic acids with alkynes/propargylic alcohols via sp2 C–H bond activation is reported. While the reaction with alkynes affords highly substituted pyrano-chromones in good to excellent yields, the use of methyl-tethered propargylic alcohols in place of alkynes leads to novel Ru(0)–metal complexes in moderate to good yields; these complexes were stable in MeCO2H/O2. The generality of the reaction with alkynes is illustrated in the case of both symmetrical and unsymmetrical internal alkynes with excellent regioselectivity in the case of unsymmetrical alkynes.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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