K2S2O8-glucose mediated oxidative coupling of alcohols with indoles for synthesis of bis(indolyl)methanes in water?
New Journal of Chemistry Pub Date: 2022-06-23 DOI: 10.1039/D2NJ02525F
Abstract
The use of inexpensive K2S2O8 in water at room temperature for synthesis of bis(indolyl)methanes (BIMs) from simple indoles and alcohols is reported. The key step involves the conversion of alcohols to their corresponding carbonyl compounds and subsequent condensation with indoles from in situ generated 
radicals. Also, the challenging aliphatic alcohols showed good performance in the synthesis of BIMs. We also carried out a detailed exploration of the mechanism.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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