One-pot synthesis of multisubstituted spirocyclopropanes mediated by α-picoline?
New Journal of Chemistry Pub Date: 2022-09-12 DOI: 10.1039/D2NJ04102B
Abstract
An efficient methodology was developed for the synthesis of multisubstituted spirocyclopropane derivatives. The reaction between isatin (acenaphthoquinone) and α-bromo(chloro)-acetophenone compounds afforded the corresponding spirocyclopropane products with high stereoselectivity via a one-pot tandem reaction in the presence of α-picoline and triethylamine. In addition, spirocyclopropanepyrazoles were obtained in good yields via a one-pot cascade reaction of α-bromo-acetophenone, pyrazolone and aromatic aldehydes. Diverse spirocyclopropane compounds were prepared through the multicomponent one-pot pathway. The high efficiency of this process and operational simplicity make it an attractive method for the synthesis of spirocyclopropanes.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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