Construction of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides and derivatives
Chemical Communications Pub Date: 2023-03-27 DOI: 10.1039/D3CC00836C
Abstract
Recent advances in the direct synthesis of trifluoromethyl-containing heterocycles from trifluoroacetimidoyl chlorides (TFAICs) and derivatives, including trifluoroacetimidohydrazides (TFAIHs) and CF3–imidoyl sulfoxonium ylides (TFISYs), are systematically summarized and discussed. The cascade annulation reactions of trifluoromethyl-containing synthons with suitable coupling partners have emerged as a powerful and promising tool for the construction of a variety of trifluoromethyl-substituted heterocycles. Compared with other trifluoromethyl-containing building blocks, TFAICs and derivatives have notable merits of easy availability and handling, relative stability and safety, and high reactivity.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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