Synthesis of two distinct pyrrole moiety-containing arenes from nitroanilines using Paal–Knorr followed by an indium-mediated reaction?
Organic & Biomolecular Chemistry Pub Date: 2015-11-12 DOI: 10.1039/C5OB02101D
Abstract
Synthesis of arenes substituted with two differently substituted-pyrrole moieties was investigated. A Paal–Knorr condensation reaction of nitroanilines with 1,4-diketone to nitrophenyl-1H-pyrroles followed by an indium-mediated reduction-triggered coupling reaction with another kind of 1,4-diketone resulted in two distinct pyrrole-containing arenes, variously substituted 1-((1H-pyrrol-1-yl)phenyl)-1H-pyrroles, in reasonable yield.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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