Synthesis of 2-amino-imidazo[4,5-b]pyridines?

Organic & Biomolecular Chemistry Pub Date: 2013-03-14 DOI: 10.1039/C3OB40413G

Abstract

The C2 amination of imidazo[4,5-b]pyridines was accomplished through C2 halogenation followed by substitution (SNAr) with functionalized primary and secondary amines. This regioselective sequence is operationally simple and provides an easy access to derivatives of protected imidazo[4,5-b]pyridines.

Graphical abstract: Synthesis of 2-amino-imidazo[4,5-b]pyridines
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