An efficient transition-metal-free route to quinazolin-4(3H)-ones via 2-aminobenzamides and thiols?
New Journal of Chemistry Pub Date: 2021-07-16 DOI: 10.1039/D1NJ03179A
Abstract
An efficient approach to quinazolin-4(3H)-ones was developed by a one-pot intermolecular annulation reaction of o-amino benzamides and thiols. This method has the features of good functional group tolerance, being transition metal and external oxidant free, and easy operation. Varieties of 2-aryl (heteroaryl) quinazolin-4(3H)-one, 2-phenyl-pyrido[2,3-d]pyrimidin-4(3H)-one and 3-phenyl-2H-1,2,4-benzo thiadiazine-1,1-dioxide derivatives were obtained with a yield of up to 98%. The control experiment revealed that the thiol substrate could promote the dehydroaromatization step.
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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