Metal-free benzannulation of yne-allenone esters for atom economical synthesis of functionalized 1-naphthols?
Green Chemistry Pub Date: 2018-06-05 DOI: 10.1039/C8GC01034J
Abstract
A new metal-free benzannulation reaction of yne-allenone esters with H2O by using HOAc as a Lewis acid promoter is reported, providing an atom economical protocol toward aroyl 1-naphthols with good to excellent yields. Exchanging H2O for aromatic amines resulted in iminated Z-1-naphthols with high stereoselectivity in a highly functional-group-compatible manner under mild conditions. The purification of these products only needs to be carried out by washing with 95% EtOH solvent, thereby avoiding traditional chromatography and recrystallization, which belongs to group-assisted purification (GAP) chemistry.
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Journal Name：Green Chemistry
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CAS no.: 89640-58-4
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