Copper-mediated C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a cyanating agent?
Chemical Communications Pub Date: 2017-06-06 DOI: 10.1039/C7CC03384B
Abstract
A copper-mediated direct C–H cyanation of (hetero)arenes with ethyl (ethoxymethylene)cyanoacetate as a safe cyanating agent has been successfully developed by using molecular oxygen as the oxidant. The reaction tolerates a variety of functional groups and provides a facile and efficient method for the synthesis of a wide range of (hetero)aryl nitriles.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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