[Gd(CyPic3A)(H2O)2]?: a stable, bis(aquated) and high-relaxivity Gd(iii) complex?

Chemical Communications Pub Date: 2013-07-24 DOI: 10.1039/C3CC44116D

Abstract

We report the synthesis and MR relevant properties of CyPic3A, a heptadentate chelator that forms ternary Gd(III) complexes of hydration state q = 2. [Gd(CyPic3A)(H2O)2]? affords an r1 value of 5.70 mM?1 s?1 at 1.41 T and 310 K and displays thermodynamic stability and kinetic inertness comparable to FDA approved MR imaging probes.

Graphical abstract: [Gd(CyPic3A)(H2O)2]?: a stable, bis(aquated) and high-relaxivity Gd(iii) complex
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