Ultrafast Grignard addition reactions in the presence of water

Organic & Biomolecular Chemistry Pub Date: 2010-06-25 DOI: 10.1039/C0OB00170H

Abstract

The addition of allylmagnesium bromide and benzylmagnesium chloride to carbonyl compounds was investigated in the presence of protic reagents such as water and the rate of carbonyl addition was found to be comparable to the rate of protonation by the reagent.

Graphical abstract: Ultrafast Grignard addition reactions in the presence of water
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