Synthesis of imidazole-activated ribonucleotides using cyanogen chloride?
Chemical Communications Pub Date: 2017-12-21 DOI: 10.1039/C7CC08489G
Abstract
We report the syntheses of ribonucleoside 5′-monophosphates activated with imidazole, using a mechanism which relies on the in situ generation of cyanogen chloride from the reaction of cyanide anion with hypochlorous acid. Cyanogen chloride reacts rapidly with imidazole to form diimidazole imine as the major product, a species which affords the activation of ribonucleoside 5′-monophosphates to their 5′-phosphorimidazolides.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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