Synthesis and biological evaluation of caulibugulones A–E?

Organic & Biomolecular Chemistry Pub Date: 2004-07-05 DOI: 10.1039/B408184F

Abstract

The marine bryozoan metabolites caulibugulone A–E were prepared from a readily available isoquinoline dione. These natural products were found to be potent and selective inhibitors of the dual specificity phosphatase Cdc25B.

Graphical abstract: Synthesis and biological evaluation of caulibugulones A–E
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