Synthesis of the cyanobacterial metabolite nostodione A, structural studies and potent antiparasitic activity against Toxoplasma gondii?
Organic & Biomolecular Chemistry Pub Date: 2015-08-12 DOI: 10.1039/C5OB01506E
Abstract
A total synthesis of the cyanobacterial natural product nostodione A is reported involving a convergent, diversity-oriented route, enabling the assembly of a mini-library of structural analogues. The first single crystal X-ray structural determination on a member of this series is reported along with SAR studies identifying potent inhibitors of invasion and replication of the parasitic protozoan Toxoplasma gondii.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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