Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues?
New Journal of Chemistry Pub Date: 2017-09-07 DOI: 10.1039/C7NJ03019C
Abstract
Herein, we report the regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues with hydroxy alkyl chains that mimic the natural C-nucleoside pseudouridine. We developed multiple disparate synthetic procedures and approaches for the preparation of a wide range of derivatives, such as amino, acyl, halogen or azido compounds. Their synthesis was based on the different reactivity of the primary and secondary hydroxy groups. The final compounds might be further considered as new building blocks for oligonucleotide synthesis.
![Graphical abstract: Regioselective synthesis of 5-[(2,3-dihydroxypropoxy)methyl]uracil analogues](http://scimg.chem960.com/usr/1/C7NJ03019C.jpg)
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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