The influence of catechol structure on the suicide-inactivation of tyrosinase

Organic & Biomolecular Chemistry Pub Date: 2009-07-09 DOI: 10.1039/B910500J

Abstract

3,6-Difluorocatechol, which cannot act as a monooxygenase tyrosinase substrate, is an oxidase substrate, and, in contrast to other catechols, oxidation does not lead to suicide-inactivation, providing experimental evidence for an inactivation mechanism involving reductive elimination of Cu0 from the active site.

Graphical abstract: The influence of catechol structure on the suicide-inactivation of tyrosinase
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