Ru-Catalyzed dehydrogenative synthesis of antimalarial arylidene oxindoles?
Organic & Biomolecular Chemistry Pub Date: 2018-09-18 DOI: 10.1039/C8OB01852A
Abstract
Ru(II)-NHC catalyzes α-olefination of 2-oxindoles using diaryl methanols in the absence of an acceptor. A wide array of symmetrical and unsymmetrical diaryl methanols undergoes dehydrogenative coupling with 2-oxindole selectively to generate various substituted 3-(diphenylmethylene)indolin-2-one derivatives in good yields and produces environmentally benign by-products, H2 and H2O. This methodology was successfully applied for the synthesis of a bioactive drug i.e. TAS-301. The biological activities of the synthesized 3-(diphenylmethylene)indolin-2-one derivatives were screened against the Plasmodium falciparum parasite and found to exhibit a significant activity with IC50 = 2.24 μM.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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