Regioselective synthesis of 3,4-disubstituted isocoumarins through the Pd-catalyzed annulation of 2-iodoaromatic acids with ynamides?
Chemical Communications Pub Date: 2016-04-18 DOI: 10.1039/C6CC01565D
Abstract
A Pd(0)-catalyzed annulation reaction of ynamides is described for the efficient synthesis of 3,4-disubstituted isocoumarins. This novel methodology allows for the concomitant construction of O–C and C–C bonds between 2-iodoaromatic acids and ynamides, exhibiting excellent regioselectivities and a wide functional group tolerance.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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