New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands
New Journal of Chemistry Pub Date: 2020-08-24 DOI: 10.1039/D0NJ03400B
Abstract
The derivatives of the 7-hydroxy-5-oxopyrazolo[4,3-b]pyridine-6-carboxamide scaffold have been reported recently as potent and selective agonists/inverse agonists of the cannabinoid type-2 receptor (CB2R), but the synthetic way adopted has not yet allowed the structure–activity relationship to be fully explored. Herein, we describe a novel synthetic approach based on the use of a 2-tetrahydropyranyl (THP)-protected precursor that opens the way to obtain either N1- or N2-substituted analogs endowed with agonist or inverse agonist activity, respectively, at the CB2 receptor.
![Graphical abstract: New synthesis of N1- and N2-substituted pyrazolo[4,3-b]pyridine-5-one derivatives as CB2 receptor ligands](http://scimg.chem960.com/usr/1/D0NJ03400B.jpg)
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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