Rational design of a Tn antigen mimic?

Chemical Communications Pub Date: 2011-03-31 DOI: 10.1039/C1CC10192G

Abstract

A novel Tn antigen mimic, in which the natural underlying amino acid has been replaced by the non-natural α-methylserine analogue, is reported. This derivative exhibits a similar affinity for a natural lectin as for the natural Tn and retains the bioactive conformation observed in the Tn-containing glycopeptides with anti-MUC1 antibodies.

Graphical abstract: Rational design of a Tn antigen mimic
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