Regiodivergent and short total synthesis of calothrixins?
Organic & Biomolecular Chemistry Pub Date: 2014-08-21 DOI: 10.1039/C4OB01309C
Abstract
The anionic annulation of MOM-protected furoindolone with 4-bromoquinoline followed by deprotection of the N-MOM group provides calothrixin B, whereas that with 3-bromoquinoline yields isocalothrixin B. The outcomes are explained by the divergence of the reaction mechanism from commonly perceived quinolyne intermediate. A sequence of addition–cyclization–elimination is proposed to account for the formation of calothrixin from 4-bromoquinoline.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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