Modular synthesis of allyl vinyl ethers for the enantioselective construction of functionalized quaternary stereocenters?
RSC Advances Pub Date: 2016-10-27 DOI: 10.1039/C6RA24284G
Abstract
A concise synthesis of 2-t-butoxycarbonyl allyl vinyl ethers by regioselective Petasis methylenation and stereoselective Suzuki–Miyaura cross-coupling reactions of iodoallyl t-butyl oxalates was developed. Ethers with a terminally unsubstituted vinyl group and a terminally disubstituted allyl portion are readily accessible by this method. The enantioselective Claisen rearrangement of representative allyl vinyl ethers was examined.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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