Nitrosyl iron complexes with enhanced NO donating ability: synthesis, structure and properties of a new type of salt with the DNIC cations [Fe(SC(NH2)2)2(NO)2]+?

New Journal of Chemistry Pub Date: 2014-11-24 DOI: 10.1039/C4NJ01693A

Abstract

Novel nitrosyl iron complexes [Fe(SC(NH2)2)2(NO)2]2SO4·H2O(I) and [Fe(SC(NH2)2)2(NO)2]2[Fe2(S2O3)2(NO)4](II) have been synthesized via the reactions of FeSO4 and Na2[Fe2(S2O3)2(NO)4], respectively, with acidic solutions of thiocarbamide in water. The structure and properties of I and II were studied using X-ray analysis, M?ssbauer, IR, and EPR spectroscopy and amperometry. Both complexes are characterized by a prolonged NO generation without additional activation in aqueous anaerobic solutions, similar to the organic NO donor diethylene triamine; however, they are more effective: at pH 7 the NO amount is ～32.6 and ～31.8 nM mol?1 of the complex for I and II, respectively. The obtained results show feasibility for the synthesis of water-soluble hybrid nitrosyl NO-generating complexes, which contain the NO groups both in the cationic and anionic sublattices and provide the control of the NO release kinetics.

Graphical abstract: Nitrosyl iron complexes with enhanced NO donating ability: synthesis, structure and properties of a new type of salt with the DNIC cations [Fe(SC(NH2)2)2(NO)2]+
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