A novel ESIPT-based fluorescent chemodosimeter for Hg2+ detection and its application in live-cell imaging?

New Journal of Chemistry Pub Date: 2017-12-08 DOI: 10.1039/C7NJ03789A

Abstract

A new excited-state intramolecular proton transfer (ESIPT) based fluorescent chemodosimeter for the detection of Hg2+ has been rationally designed and developed. The probe operates via the specific mercury-promoted desulfurization reaction of thiophthalimide to phthalimide and exhibits high selectivity and sensitivity in an almost pure aqueous solution (containing only 1% DMSO) with a low detection limit of 1.5 ppb. Furthermore, the probe was successfully used for the fluorescence imaging of Hg2+ in live cells.

Graphical abstract: A novel ESIPT-based fluorescent chemodosimeter for Hg2+ detection and its application in live-cell imaging
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