Highly-efficient and versatile fluorous-tagged Cu(i)-catalyzed azide–alkyne cycloaddition ligand for preparing bioconjugates?
Chemical Communications Pub Date: 2015-09-25 DOI: 10.1039/C5CC06858D
Abstract
A novel ligand (FBTTBE) for Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) has been developed, which demonstrates not only superior catalytic efficiency but also the ease of removing toxic copper species. FBTTBE has also been successfully applied in the synthesis of radiometal-labeled peptide and antibody without observable transchelation with the non-radioactive Cu(I) catalyst.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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