Heteromolecular compounds in binary systems of amino acids with opposite and same chiralities?

CrystEngComm Pub Date: 2020-01-14 DOI: 10.1039/C9CE01333D

Abstract

A classification of discrete compounds in binary chiral systems of single and different substances (homo- and heteromolecular compounds) is presented. It considers both chemical and crystallographic characteristics of such compounds. Using amino acids as chiral model systems, features of crystal structures of equimolar and non-equimolar heteromolecular compounds are reviewed. In this connection, the concept of homo- and heteromolecular dimers in compounds formed by amino acids is introduced and analyzed. As a result, a correlation between the molecular dimer type and the side chain structure (linear or branched) and the conformation (extended or folded) of the relevant compounds' molecules is derived. Two non-equimolar discrete heterocompounds discovered in the chiral systems L-valine–L-isoleucine and L-valine–L-leucine are discussed using the concepts proposed. The previously studied first system features a 2?:?1 (Val?:?Ile) compound. A newly investigated second system is found to form a 3?:?1 (Val?:?Leu) compound, and its crystal structure is described and evaluated.

Graphical abstract: Heteromolecular compounds in binary systems of amino acids with opposite and same chiralities
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