Electrophilic ring fluorination of 3,5-disubstituted pyrazoles: application to the formal synthesis of a neprilysin inhibitor key intermediate??
New Journal of Chemistry Pub Date: 2020-11-16 DOI: 10.1039/D0NJ05222A
Abstract
The access to a new family of unusual 4-fluorinated pyrazoles bearing acetal moities at the 3- or 5-position has been achieved by electrophilic fluorination using Selectfluor? with yields up to 67%. The unconverted starting material can be recovered and recycled. This reaction has been successfully applied to the formal synthesis of a key intermediate in the synthesis of neprilysin inhibitors with 42% overall yield (5 steps).
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Journal Name：New Journal of Chemistry
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CAS no.: 89640-58-4
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