Electroorganic synthesis of nitriles via a halogen-free domino oxidation–reduction sequence?

Chemical Communications Pub Date: 2015-09-17 DOI: 10.1039/C5CC06437F

Abstract

A direct electroorganic sequence yielding nitriles from oximes in undivided cells is reported. Despite the fact that intermediate nitrile oxides might be formed, the method is viable to prepare benzonitriles without substituents ortho to the aldoxime moiety. This constant current method is easy to perform for a broad scope of substrates and employs common electrodes, such as graphite and lead.

Graphical abstract: Electroorganic synthesis of nitriles via a halogen-free domino oxidation–reduction sequence
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