A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase?

Chemical Communications Pub Date: 2016-02-25 DOI: 10.1039/C6CC00095A

Abstract

Copper/zinc superoxide dismutase (Cu/Zn SOD) is an essential enzyme that protects tissue from oxidative damage. Herein we report the first fluorogenic probe (SODO) for the detection and in vivo imaging of Cu/Zn SOD. SODO represents a unique chemical probe for translational imaging studies of Cu/Zn SOD in inflammatory disorders.

Graphical abstract: A highly selective fluorogenic probe for the detection and in vivo imaging of Cu/Zn superoxide dismutase
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