1-Ethynylpyrene-modified guanine and cytosine as optical labels for DNA hybridization?

Organic & Biomolecular Chemistry Pub Date: 2005-05-04 DOI: 10.1039/B504079E

Abstract

1-Ethynylpyrene shows remarkable absorption changes upon DNA hybridization when it is covalently attached to the 8-position of guanine. An absorption band at ~420 nm is only present in the duplex, exhibits thermal melting behaviour and provides the basis for a molecular beacon together with 1-ethynylpyrene-modified cytosine.

Graphical abstract: 1-Ethynylpyrene-modified guanine and cytosine as optical labels for DNA hybridization
Recommended Literature