Copper-catalyzed C–H alkylation of 8-aminoquinolines via 8-amide chelation assistance?
RSC Advances Pub Date: 2015-03-18 DOI: 10.1039/C4RA16896H
Abstract
A copper-catalyzed 8-amide chelation-assisted C–H alkylation of 8-aminoquinolines is described. The secondary and tertiary alkyl carboxylic acids can be used as alkylating agents. This reaction allows for the highly regioselective preparation of C2-adamantyl 8-aminoquinoline scaffolds by the decarboxylative alkylation catalytic system.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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