Copper-catalyzed enantioselective Mannich reaction between N-acylpyrazoles and isatin-derived ketimines?
Organic Chemistry Frontiers Pub Date: 2019-06-11 DOI: 10.1039/C9QO00575G
Abstract
A copper-catalyzed enantioselective Mannich reaction between N-acylpyrazoles and isatin-derived ketimines is developed. With 5 mol% Cu(CH3CN)4PF6 complexed with 6 mol% chiral amidophosphine ligand L8, 3-substituted 3-amino-2-oxindoles with contiguous stereocenters were produced in 92–99% yields with excellent diastereoselectivities (97?:?3 to 99?:?1 dr) and 94–99% ee under mild conditions.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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