Cobalt-catalyzed selective hydroacylation of alkynes?
Organic Chemistry Frontiers Pub Date: 2021-09-02 DOI: 10.1039/D1QO00964H
Abstract
An efficient protocol has been reported for alkyne hydroacylation using a catalytic system incorporating Co(acac)3, dppp and AlMe3 at 160 °C. The reaction proceeds through oxidative cyclization/β-H elimination to afford a series of α,β-unsaturated ketones. The present protocol features no need for chelating groups, the use of inexpensive and bench-stable precatalysts, and wide substrate scope.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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