Maleimides
Maleimides are a class of organic compounds characterized by the presence of a maleimide functional group, typically represented as C=C(S). These reagents play a crucial role in various chemical syntheses and applications due to their unique reactive properties. Maleimides can undergo Michael addition reactions with nucleophiles containing a carbon-labile bond, such as alkenes or thiols, making them valuable tools in organic synthesis.
In the pharmaceutical industry, maleimides are used for site-specific conjugation of drugs to proteins, thereby enhancing drug targeting and stability. They also find applications in polymer chemistry where they can be employed for controlled radical polymerization processes. Additionally, maleimides are utilized in materials science for the production of biocompatible polymers and coatings due to their ability to form strong covalent bonds.
Overall, maleimides offer a versatile platform for chemical modification and synthesis, with wide-ranging applications across various fields including drug development, polymer engineering, and biomaterials.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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1H-Pyrrole-2,5-dione, 1-(2-mercaptoethyl)-3,4-dimethyl- | 88595-29-3 | C8H11NO2S |
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N-Ethyl-d5-maleimide | 360768-37-2 | C6H7NO2 |
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1-benzyl-3-methyl-2,5-dihydro-1H-pyrrole-2,5-dione | 73383-82-1 | C12H11NO2 |
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1-Butyl-1H-pyrrole-2,5-dione | 2973-09-3 | C8H11NO2 |
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N-Hydroxymaleimide | 4814-74-8 | C4H3NO3 |
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4-Maleimidobutyric acid hydrazide | 181148-01-6 | C8H11N3O3 |
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Cyclopenta[c]pyrrole-1,3(2H,4H)-dione,5,6-dihydro-4-hydroxy-, (+)- | 50988-16-4 | C7H7NO3 |
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3-Maleimido-PROXYL | 5389-27-5 | C12H17N2O3 |
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1-(5-Aminopentyl)-1H-pyrrole-2,5-dione Hydrochloride | 510709-83-8 | C9H15ClN2O2 |
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BMB Crosslinker | 28537-70-4 | C12H12N2O4 |
Related Literature
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Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
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J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608
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Maomao Hou,Fenglin Zhong,Qiu Jin,Enjiang Liu,Jie Feng,Tengyun Wang,Yue Gao RSC Adv., 2017,7, 34392-34400
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Gaurav J. Shah,Eric P.-Y. Chiou,Ming C. Wu,Chang-Jin “CJ” Kim Lab Chip, 2009,9, 1732-1739
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Yukiya Kitayama Polym. Chem., 2014,5, 2784-2792
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