Maleimides
Maleimides are a class of organic compounds characterized by the presence of a maleimide functional group, typically represented as C=C(S). These reagents play a crucial role in various chemical syntheses and applications due to their unique reactive properties. Maleimides can undergo Michael addition reactions with nucleophiles containing a carbon-labile bond, such as alkenes or thiols, making them valuable tools in organic synthesis.
In the pharmaceutical industry, maleimides are used for site-specific conjugation of drugs to proteins, thereby enhancing drug targeting and stability. They also find applications in polymer chemistry where they can be employed for controlled radical polymerization processes. Additionally, maleimides are utilized in materials science for the production of biocompatible polymers and coatings due to their ability to form strong covalent bonds.
Overall, maleimides offer a versatile platform for chemical modification and synthesis, with wide-ranging applications across various fields including drug development, polymer engineering, and biomaterials.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)-6-phenyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carbonitrile | 920478-39-3 | C19H14N2O2S |
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mPEG12-Mal | 88504-24-9 | C32H58N2O15 |
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1-(4-aminobutyl)-2,5-dihydro-1H-pyrrole-2,5-dione | 945530-68-7 | C8H12N2O2 |
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1H-Pyrrole-2,5-dione, 3,4-dimethoxy-1-methyl- | 122275-40-5 | C7H9NO4 |
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1H-Pyrrole-2,5-dione, 1-(5-hydroxypentyl)- | 180608-78-0 | C9H13NO3 |
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1H-Pyrrole-2,5-dione, 1-(5-bromo-2-pyridinyl)-3-methyl- | 330942-91-1 | C10H7BrN2O2 |
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1-(2-methylbutan-2-yl)-2,5-dihydro-1H-pyrrole-2,5-dione | 127397-40-4 | C9H13NO2 |
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Mal-peg1-ch2cooh | 1354714-66-1 | C8H9NO5 |
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m-PEG1-Mal | 1566615-85-7 | C10H14N2O4 |
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3-(3,4-dimethyl-2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)propanoic acid | 63945-03-9 | C9H11NO4 |
Related Literature
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Stephen P. Fletcher,Richard B. C. Jagt,Ben L. Feringa Chem. Commun., 2007, 2578-2580
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Yu-Nong Li,Liang-Nian He,Xian-Dong Lang,Xiao-Fang Liu,Shuai Zhang RSC Adv., 2014,4, 49995-50002
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Kanjun Sun,Fengting Hua,Shuzhen Cui,Yanrong Zhu,Hui Peng,Guofu Ma RSC Adv., 2021,11, 37631-37642
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Chengbin Yang,Hing Lun Tsang,Pui Man Lau,Ken-Tye Yong,Ho Pui Ho,Siu Kai Kong Analyst, 2017,142, 3579-3587
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Piotr Szcze?niak,Sebastian Stecko RSC Adv., 2015,5, 30882-30888
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