Fluorine containing Building Blocks
Fluorinated Building Blocks: These advanced chemical entities are designed for the synthesis of fluorine-containing compounds, offering unique reactivity and stability not found in non-fluorinated analogues. Fluorinated building blocks are particularly useful in medicinal chemistry due to their ability to modulate biological activity by introducing fluorine atoms at strategic positions. They can enhance lipophilicity, increase metabolic stability, and improve drug permeability through cell membranes, making them indispensable tools for the development of novel therapeutic agents.
These砌塊通常包含功能化的氟原子,能夠有效地參與多種有機反應,如親核取代、傅克?;龋瑥亩鴰椭瘜W家構建具有特定生物活性的分子。由于其獨特的物理和化學性質,含氟砌塊在合成復雜藥物分子時展現出顯著優(yōu)勢,是現代藥物設計不可或缺的一部分。
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2,3,4,5-Tetrafluorobenzaldehyde | 16583-06-5 | C7H2F4O |
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1,1,2,2-Tetrafluoroethyl2,2,3,3-tetrafluoropropylether | 16627-68-2 | C5H4F8O |
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3-(Trifluoromethoxy)benzaldehyde | 52771-21-8 | C8H5F3O2 |
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1,2-dibromotetrafluoroethane | 124-73-2 | C2Br2F4 |
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5-Fluoro-2-nitrobenzoic acid | 320-98-9 | C7H4FNO4 |
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4-Fluoro-2-methylbenzoic acid | 321-21-1 | C8H7FO2 |
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4-fluorobenzene-1,2-diol | 367-32-8 | C6H5FO2 |
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3-(Trifluoromethyl)benzonitrile | 368-77-4 | C8H4F3N |
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4,4,4-Trifluoro Ethyl Ester Butanoic Acid | 371-26-6 | C6H9F3O2 |
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1H,1H,9H-Hexadecafluoro-1-nonanol | 376-18-1 | C9H4F16O |
Related Literature
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Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
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J. Zagora,M. Vosla?,L. Schreiberová,I. Schreiber Phys. Chem. Chem. Phys., 2002,4, 1284-1291
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