| Related Categories | No. | Product Name | Cas No. | Purity | Specification | Price | update time | Inquiry |
|---|---|---|---|---|---|---|---|---|
| SHANG HAI MAI KE LIN SHENG HUA Technology Co., Ltd. | T906037-250mg |
2-tert-butyl-6-chloropyridine |
97691-23-1 | 95% | 250mg |
1,710.00 | 2021-05-17 | |
| Chemenu | CM362480-1g |
2-(tert-butyl)-6-chloropyridine |
97691-23-1 | 95%+ | 1g |
$527 | 2022-06-09 | |
| eNovation Chemicals LLC | D643996-1g |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 1g |
$380 | 2024-07-28 | |
| eNovation Chemicals LLC | D643996-5g |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 5g |
$920 | 2024-07-28 | |
| eNovation Chemicals LLC | Y1004076-5g |
2-tert-butyl-6-chloropyridine |
97691-23-1 | 95% | 5g |
$900 | 2024-07-24 | |
| eNovation Chemicals LLC | D643996-2g |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 2g |
$540 | 2024-07-28 | |
| eNovation Chemicals LLC | D643996-10g |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 10g |
$1490 | 2024-07-28 | |
| Aaron | AR01FQKX-100mg |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 100mg |
$62.00 | 2025-02-10 | |
| Aaron | AR01FQKX-250mg |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 250mg |
$124.00 | 2025-02-10 | |
| Aaron | AR01FQKX-1g |
2-chloro-6-(1,1-dimethylethyl)-Pyridine |
97691-23-1 | 97% | 1g |
$342.00 | 2025-02-10 |
2-(Tert-Butyl)-6-chloropyridine, with the chemical formula C11H13ClN, is a significant intermediate in modern pharmaceutical and agrochemical research. This compound, identified by its CAS number 97691-23-1, has garnered attention due to its versatile structural properties and potential applications in drug development. The presence of both a chloro substituent and a tert-butyl group makes it a valuable building block for synthesizing more complex molecules.
The tert-butyl group, characterized by its steric hindrance, plays a crucial role in modulating the reactivity and selectivity of the pyridine core. This feature is particularly useful in medicinal chemistry, where controlling the three-dimensional arrangement of atoms can influence binding affinity and metabolic stability. In contrast, the chloro substituent at the 6-position introduces electrophilic centers, facilitating further functionalization through nucleophilic aromatic substitution or cross-coupling reactions.
Recent advancements in synthetic methodologies have highlighted the utility of 2-(Tert-Butyl)-6-chloropyridine in constructing heterocyclic frameworks. For instance, studies have demonstrated its effectiveness in generating substituted pyridines, which are prevalent motifs in bioactive compounds. Researchers have leveraged its reactivity to develop novel derivatives with enhanced pharmacological properties. These derivatives exhibit promise in treating neurological disorders, infectious diseases, and cancer by targeting specific biological pathways.
In the realm of agrochemicals, 2-(Tert-Butyl)-6-chloropyridine has been explored as a precursor for herbicides and fungicides. Its structural features contribute to improved crop protection by interfering with essential enzymatic processes in pests. The integration of computational modeling has further refined the design of these agrochemicals, ensuring higher efficacy while minimizing environmental impact.
The synthesis of 2-(Tert-Butyl)-6-chloropyridine typically involves chlorination and alkylation reactions starting from pyridine derivatives. Modern synthetic routes emphasize atom economy and green chemistry principles, reducing waste and energy consumption. For example, catalytic methods employing palladium or copper complexes have been optimized to achieve high yields with minimal byproducts.
From a mechanistic perspective, the reactivity of 2-(Tert-Butyl)-6-chloropyridine has been extensively studied to understand its role in cross-coupling reactions such as Suzuki-Miyaura and Buchwald-Hartwig couplings. These transformations are pivotal in constructing biaryl systems, which are integral to many pharmaceuticals. The tert-butyl group’s steric bulk often directs these reactions toward specific regioisomers, enhancing synthetic control.
The pharmaceutical industry has shown particular interest in 2-(Tert-Butyl)-6-chloropyridine due to its role as a scaffold for kinase inhibitors. Kinases are critical targets in oncology, and modulating their activity can lead to therapeutic breakthroughs. Researchers have synthesized analogs of this compound that exhibit potent inhibitory effects on aberrant signaling pathways associated with cancer cell proliferation.
Additionally, 2-(Tert-Butyl)-6-chloropyridine has been investigated for its potential in developing antiviral agents. The pyridine core is a common structural element in drugs that disrupt viral replication cycles. By modifying the substituents on this core, scientists aim to create molecules that can selectively inhibit viral enzymes without affecting host cells.
The agrochemical sector has also benefited from the versatility of 2-(Tert-Butyl)-6-chloropyridine. Its derivatives have been incorporated into formulations that offer broad-spectrum pest control while adhering to stringent regulatory standards. The compound’s stability under various environmental conditions ensures prolonged activity, reducing the frequency of application required.
In conclusion, 2-(Tert-Butyl)-6-chloropyridine (CAS No. 97691-23-1) represents a cornerstone in synthetic chemistry with far-reaching implications across multiple industries. Its unique structural features enable diverse applications in pharmaceuticals and agrochemicals, driven by ongoing research into novel derivatives and reaction pathways. As scientific understanding evolves, this compound will likely continue to play a pivotal role in advancing chemical innovation.
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