2-halopyridines
2-Halo Pyridines are a class of organic compounds containing a pyridine ring with a halogen substituent at the 2-position. These compounds exhibit unique electronic properties due to the presence of the halogen, which can significantly alter their reactivity and solubility characteristics. Halogen substitution in this position often leads to enhanced electrophilicity, making 2-halo pyridines valuable intermediates in various organic synthesis reactions. They find applications in pharmaceuticals, agrochemicals, and materials science, where specific functional groups are required for targeted molecular interactions or properties. The choice of halogen (fluorine, chlorine, bromine) can further tailor the physical and chemical properties of these compounds to meet diverse synthetic requirements.
| Structure | Chemical Name | CAS | MF |
|---|---|---|---|
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2-(6-bromopyridin-3-yl)acetaldehyde | 722535-98-0 | C7H6BrNO |
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6-fluoro-3-hydroxypyridine-2-carbonitrile | 727736-71-2 | C6H3FN2O |
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2-Fluoro isonornicotine | 1270485-14-7 | C9H11FN2 |
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5-(chloromethyl)-2-fluoropyridine | 315180-15-5 | C6H5ClFN |
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(6-fluoropyridin-2-yl)methanol | 315180-17-7 | C6H6FNO |
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2-Chloro-6-methylpyridin-3-ol | 35680-24-1 | C6H6ClNO |
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2-chloro-5-(1H-imidazol-4-yl)pyridine | 790262-70-3 | C8H6ClN3 |
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5-(N-Boc-Aminomethyl)-2-Bromopyridine | 864266-29-5 | C11H15BrN2O2 |
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3-(6-Bromo-pyridin-2-Yl)-isoxazol-5-ylamine | 887595-06-4 | C8H6BrN3O |
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2-bromo-5-(3-bromopropyl)pyridine | 918145-48-9 | C8H9Br2N |
Related Literature
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Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
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Hui Liu,Deyong Su,Guolin Cheng,Jimin Xu,Xinyan Wang,Yuefei Hu Org. Biomol. Chem., 2010,8, 1899-1904
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Bruce Parkinson Energy Environ. Sci., 2010,3, 509-511
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Dan Yang,Yanping Zhou,Xianhong Rui,Jixin Zhu,Ziyang Lu,Eileen Fong,Qingyu Yan RSC Adv., 2013,3, 14960-14962
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Jing Yu,Yu-Qi Lyu,Jiapeng Liu,Mohammed B. Effat,Junxiong Wu J. Mater. Chem. A, 2019,7, 17995-18002
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