Production Method 1

5326-23-8

97455-61-3

Reaction Conditions

1.1 Reagents: Sodium hydroxide Catalysts: Tetrabutylammonium bromide Solvents: Toluene ;  6 h, 120 °C; overnight, 120 °C → rt; 8 h, 120 °C
1.2 Reagents: Hydrochloric acid Solvents: Water ;  acidified
1.3 Reagents: Borane Solvents: Tetrahydrofuran ;  rt → 0 °C; 1 h, 0 °C; 0 °C → rt; 4 h, rt; rt → 0 °C
1.4 Reagents: Methanol ;  overnight, 0 °C
1.5 Reagents: Manganese oxide (MnO2) Solvents: Toluene ;  2 h, rt → reflux; 2.5 h, reflux

Reference

Preparation of piperazinecarboxamides as CCR2b antagonists

, World Intellectual Property Organization, , ,

Production Method 2

55849-30-4

97455-61-3

Reaction Conditions

1.1 Reagents: Butyllithium Solvents: Tetrahydrofuran ,  Hexane ;  -68 °C; 0.5 h, -68 °C
1.2 -68 °C; -68 °C → rt; 3 h, rt

Reference

Novel indirect amp-activated protein kinase activators: identification of a second-generation clinical candidate with improved physicochemical properties and reduced hERG inhibitory activity

Kuramoto, Kazuyuki; Sawada, Yuki; Yamada, Tomohiro; Nagashima, Takeyuki; Ohnuki, Kei; et al, Chemical & Pharmaceutical Bulletin, 2020, 68(5), 452-465

Production Method 3

97455-65-7

97455-61-3

Reaction Conditions

1.1 Reagents: Lithium aluminum hydride Solvents: Tetrahydrofuran ;  16 h, 0 °C
1.2 Reagents: Potassium sodium tartrate Solvents: Ethyl acetate ,  Water ;  1 h, rt
1.3 Reagents: Manganese oxide (MnO2) Solvents: Acetonitrile ;  24 h, rt

Reference

Preparation of tricyclic piperidine compounds, particularly imidazodipyridines, as inhibitors of tryptophan hydroxylase

, World Intellectual Property Organization, , ,

Production Method 4

101990-67-4

97455-61-3

Reaction Conditions

Reference

Preparation of N-pyridylalkyl-1-[(hetero)aryl]aminoethanols as animal growth stimulants and antiobesity agents

, European Patent Organization, , ,

6-ethoxypyridine-3-carbaldehyde Raw materials

• 6-ethoxy-3-Pyridinemethanol
• 6-ethoxypyridine-3-carboxylic acid
• 5-Bromo-2-ethoxypyridine
• 6-chloropyridine-3-carboxylic acid

6-ethoxypyridine-3-carbaldehyde Preparation Products

• 6-ethoxypyridine-3-carbaldehyde (97455-61-3)

• 1. Fe(iii)-mediated isomerization of α,α-diarylallylic alcohols to ketones via radical 1,2-aryl migration?
  Ziyang Deng,Changwei Chen,Sunliang Cui RSC Adv., 2016,6, 93753-93755
• 2. Establishment and implications of a characterization method for magnetic nanoparticle using cell tracking velocimetry and magnetic susceptibility modified solutions
  Huading Zhang,Lee R. Moore,Maciej Zborowski,P. Stephen Williams,Shlomo Margel,Jeffrey J. Chalmers Analyst, 2005,130, 514-527
• 3. Evolution of shape, size, and areal density of a single plane of Si nanocrystals embedded in SiO2 matrix studied by atom probe tomography
  Bin Han,Yasuo Shimizu,Gabriele Seguini,Celia Castro,Gérard Ben Assayag,Koji Inoue,Yasuyoshi Nagai,Sylvie Schamm-Chardon,Michele Perego RSC Adv., 2016,6, 3617-3622
• 4. Exciting clusters, what does off-resonance actually mean??
  Goonay Yousefalizadeh,Shideh Ahmadi,Nicholas J. Mosey,Kevin G. Stamplecoskie Nanoscale, 2021,13, 242-252
• 5. Evidence of pre-micellar aggregates in aqueous solution of amphiphilic PDMS–PEO block copolymer?
  Domenico Lombardo,Gianmarco Munaò,Pietro Calandra,Luigi Pasqua,Maria Teresa Caccamo Phys. Chem. Chem. Phys., 2019,21, 11983-11991

• Solvents and Organic Chemicals Organic Compounds Organoheterocyclic compounds Pyridines and derivatives Pyridine carboxaldehydes

• 66572-55-2(6-methoxypyridine-3-carboxylic acid)
• 94084-76-1(6-(Benzyloxy)nicotinic Acid)
• 65873-72-5(6-methoxypyridine-3-carbaldehyde)
• 820237-46-5(3-Pyridinecarboxaldehyde, 2,6-dipropoxy-)
• 1289173-12-1(6-Isopropoxy-4-methylnicotinaldehyde)
• 884495-35-6(5-Formyl-2-isoproxypyridine)
• 97455-65-7(6-ethoxypyridine-3-carboxylic acid)
• 885278-07-9(2-Ethoxynicotinaldehyde)
• 123506-66-1(6-methoxy-4-methyl-pyridine-3-carbaldehyde)
• 885278-12-6(2-propoxypyridine-3-carbaldehyde)