Production Method 1

6148-64-7

18063-02-0

97305-12-9

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Acetonitrile ;  10 - 15 °C; 2.5 h, rt; rt → 0 °C
1.2 Reagents: Triethylamine ;  rt; rt → 15 °C
1.3 Reagents: Hydrochloric acid Solvents: Water ;  rt

Reference

Reinvestigation of prototropic photochromism: 3-benzoyl-2-benzylchromones

Rossollin, V.; Lokshin, V.; Samat, A.; Guglielmetti, R., Tetrahedron, 2003, 59(39), 7725-7731

Production Method 2

6148-64-7

18063-02-0

97305-12-9

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Acetonitrile ;  0 °C; 3.5 h, rt; rt → 0 °C
1.2 0 °C; 1.5 h, 0 °C; 2 h, rt

Reference

Herbicidal cinnoline derivatives and their preparation

, World Intellectual Property Organization, , ,

Production Method 3

18063-02-0

1071-46-1

97305-12-9

Reaction Conditions

Reference

Pollen suppressant comprising a fused pyridazine

, European Patent Organization, , ,

Production Method 4

6148-64-7

18063-02-0

97305-12-9

Reaction Conditions

1.1 Reagents: Triethylamine ,  Magnesium chloride Solvents: Acetonitrile ;  0 °C; 3.5 h, rt; rt → 0 °C
1.2 0 °C; 1.5 h, 0 °C; 2 h, rt; 18 h, rt

Reference

Herbicidal cinnoline derivatives

, World Intellectual Property Organization, , ,

Production Method 5

6148-64-7

385-00-2

97305-12-9

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Acetonitrile ;  2 h, 25 °C
1.2 Reagents: Triethylamine ,  Magnesium chloride Solvents: Acetonitrile ;  25 °C; 2 h, 50 °C; 12 h, 70 °C
1.3 Reagents: Hydrochloric acid Solvents: Water

Reference

Preparation of non-macrocyclic α-keto amide compounds as calpain modulators

, World Intellectual Property Organization, , ,

Production Method 6

18063-02-0

97305-12-9

Reaction Conditions

1.1 Reagents: Lithium Solvents: Ethyl acetate ;  30 min, cooled; rt
1.2 Reagents: Ammonium chloride Solvents: Water ;  rt

Reference

Pyrazole derivatives as inhibitors of lactate dehydrogenase and their preparation

, World Intellectual Property Organization, , ,

Production Method 7

6148-64-7

385-00-2

97305-12-9

Reaction Conditions

1.1 Reagents: 1,1′-Carbonyldiimidazole Solvents: Tetrahydrofuran ;  6 h, rt
1.2 Reagents: Magnesium chloride Solvents: Tetrahydrofuran ;  6 h, 50 - 60 °C; 60 °C → rt; 18 h, rt; 3 h, reflux; reflux → rt
1.3 Reagents: Hydrochloric acid Solvents: Water ;  < pH 2, rt

Reference

Pyrazolo[4,3-c]cinnolin-3-one derivatives as M1 receptor positive allosteric modulators and their preparation, pharmaceutical compositions and use in the treatment of diseases

, World Intellectual Property Organization, , ,

Production Method 8

18063-02-0

1071-46-1

97305-12-9

Reaction Conditions

Reference

Preparation of a fused pyridazinone as pollen suppressants

, United States, , ,

Production Method 9

97305-12-9

Reaction Conditions

Reference

Cytotoxic quinolines. Part 3. Synthesis of 1-azolylalkyl-4(1H)-quinolones as cytotoxic agents

Abel, Mark D.; Micetich, Ronald G.; Nukatsuka, Mamoru; Oreski, A. Bernadette; Tempest, Mark L.; et al, Drug Design and Discovery, 1996, 14(2), 115-127

Production Method 10

97305-12-9

Reaction Conditions

Reference

Preparation of β-keto carboxylic acid esters from malonates and benzoyl fluorides

, Japan, , ,

Ethyl (2,6-Difluorobenzoyl)acetate Raw materials

• Ethyl potassium malonate
• 2,6-Difluorobenzoic acid
• 2,6-Difluorobenzoyl chloride
• 3-ethoxy-3-oxo-propanoic acid

Ethyl (2,6-Difluorobenzoyl)acetate Preparation Products

• Ethyl (2,6-Difluorobenzoyl)acetate (97305-12-9)

• 1. Excitonic and vibrational coherence in artificial photosynthetic systems studied by negative-time ultrafast laser spectroscopy
  Dongjia Han,Bing Xue,Juan Du,Tomohiro Miyatake,Hitoshi Tamiaki,Xin Xing,Wei Yuan,Yanyan Li Phys. Chem. Chem. Phys., 2016,18, 24252-24260
• 2. Exchangeability of amino acid residues with similar physicochemical properties in coiled-coil interactions?
  Guiying Zhang,Maosheng Cheng,Yanni Li,Keliang Liu,Lifeng Cai Chem. Commun., 2013,49, 11086-11088
• 3. Evidence that the availability of an allylic hydrogen governs the regioselectivity of the Wacker oxidation
  Matthew J. Gaunt,Jinquan Yu,Jonathan B. Spencer Chem. Commun., 2001, 1844-1845
• 4. Emulsion soft templating of carbide-derived carbon nanospheres with controllable porosity for capacitive electrochemical energy storage?
  M. Zeiger,N. J?ckel,P. Strubel,L. Borchardt,R. Reinhold,W. Nickel,J. Eckert,V. Presser,S. Kaskel J. Mater. Chem. A, 2015,3, 17983-17990
• 5. Evidence of rutile-to-anatase photo-induced electron transfer in mixed-phase TiO2 by solid-state NMR spectroscopy?
  Weili Dai,Guangjun Wu,Michael Hunger Chem. Commun., 2015,51, 13779-13782

• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Ketones
• Solvents and Organic Chemicals Organic Compounds Organic oxygen compounds Organooxygen compounds Carbonyl compounds Ketones

• 98349-24-7(ethyl 3-oxo-3-(2,4,5-trifluorophenyl)propanoate)
• 58101-23-8(ethyl 3-(2,4-difluorophenyl)-3-oxo-propanoate)
• 898753-06-5(ethyl 4-(2,4-difluorophenyl)-4-oxo-butanoate)
• 185302-85-6(Methyl 3-(2,4-difluorophenyl)-3-oxopropanoate)
• 185302-86-7(Methyl 3-(2-fluorophenyl)-3-oxopropanoate)
• 887267-53-0(Ethyl 3-(2,5-difluorophenyl)-3-oxopropanoate)
• 3516-87-8(ethyl (pentafluorobenzoyl)acetate)
• 94695-50-8(2,3,4,5-Tetrafluorobenzoylacetic Acid Ethyl Ester)
• 1479-24-9(Ethyl 3-(2-fluorophenyl)-3-oxopropanoate)
• 112822-88-5(Ethyl 3-oxo-3-(2,4,5-trifluoro-3-methylphenyl)propanoate)