Production Method 1

56990-02-4

97165-77-0

Reaction Conditions

1.1 Reagents: Imidazolium chloride ,  Hydroxyamine hydrochloride Solvents: Sulfolane ;  4 h, 120 °C

Reference

Imidazole Hydrochloride Promoted Synthesis of Nitriles from Aldehydes

Wang, Yin; Wang, Xuetong; Li, Yanwu; Zhang, Xiuyu; Li, Lingli; et al, Current Organic Synthesis, 2022, 19(8), 923-929

Production Method 2

145691-59-4

97165-77-0

Reaction Conditions

1.1 Reagents: Ammonia ,  Oxygen Catalysts: Ruthenium (manganese oxide nanorod-supported) Solvents: 2-Methyl-2-butanol ,  Water ;  5.5 h, 0.5 MPa, 100 °C

Reference

Atomically Dispersed Ru on Manganese Oxide Catalyst Boosts Oxidative Cyanation

Wang, Hai; Xu, Dongyang; Guan, Erjia ; Wang, Liang ; Zhang, Jian; et al, ACS Catalysis, 2020, 10(11), 6299-6308

Production Method 3

145691-59-4

97165-77-0

Reaction Conditions

1.1 Reagents: Ammonia ,  Oxygen Catalysts: Cobalt oxide (Co3O4) (reaction product with Vulcan XC72R and 1,10-phenanthroline) Solvents: 2-Methyl-2-butanol ,  Water ;  24 h, 5 bar, 130 °C

Reference

Green synthesis of nitriles using non-noble metal oxides-based nanocatalysts

Jagadeesh, Rajenahally V.; Junge, Henrik; Beller, Matthias, Nature Communications, 2014, 5,

Production Method 4

145691-59-4

97165-77-0

Reaction Conditions

1.1 Reagents: Ammonia ,  Oxygen Catalysts: Boron nitride (sulfonated) Solvents: Water ;  8 h, 80 °C

Reference

Method for synthesis of nitriles by ammoxidation of aromatic alcohols using metal-free sulfonated boron nitride as catalyst

, India, , ,

Production Method 5

97165-77-0

Reaction Conditions

1.1 Reagents: Sodium bromide ,  Hydrogen peroxide ,  Hydrogen bromide

Reference

Halogenation of benzene derivatives with electron-acceptor substituents under conditions generating electrophilic chlorine and bromine

Sadiqov, O. A., Kimya Problemlari, 2009, (4), 676-679

3,5-Dibromobenzonitrile Raw materials

• 3,5-Dibromobenzaldehyde
• (3,5-dibromophenyl)methanol

3,5-Dibromobenzonitrile Preparation Products

• 3,5-Dibromobenzonitrile (97165-77-0)

• 1. Emerging investigator series: heterogeneous reactions of sulfur dioxide on mineral dust nanoparticles: from single component to mixed components?
  Tao Wang,Yangyang Liu,Yue Deng,Hongbo Fu,Jianmin Chen Environ. Sci.: Nano, 2018,5, 1821-1833
• 2. Evolution of hierarchical porous structures in supramolecular guest–host hydrogels?
  Christopher B. Rodell,Christopher B. Highley,Minna H. Chen,Neville N. Dusaj,Chao Wang,Lin Han,Jason A. Burdick Soft Matter, 2016,12, 7839-7847
• 3. Evolved polymerases facilitate selection of fully 2′-OMe-modified aptamers?
  Zhixia Liu,Tingjian Chen,Floyd E. Romesberg Chem. Sci., 2017,8, 8179-8182
• 4. Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides?
  Chen-Yu Chien,Sheng-Sheng Yu Chem. Commun., 2020,56, 11949-11952
• 5. Enabling chloride salts for thermal energy storage: implications of salt purity?
  J. Matthew Kurley,Phillip W. Halstenberg,Abbey McAlister,Stephen Raiman,Richard T. Mayes RSC Adv., 2019,9, 25602-25608

• Solvents and Organic Chemicals Organic Compounds Benzenoids Benzene and substituted derivatives Benzonitriles
• Solvents and Organic Chemicals Organic Compounds cyanides/Cyanides

Recent Advances in the Study of 3,5-Dibromobenzonitrile (CAS: 97165-77-0) in Chemical Biology and Pharmaceutical Research

3,5-Dibromobenzonitrile (CAS: 97165-77-0) is a halogenated aromatic compound that has garnered significant attention in recent years due to its versatile applications in chemical biology and pharmaceutical research. This compound, characterized by its bromine substituents and nitrile functional group, serves as a key intermediate in the synthesis of various bioactive molecules. Recent studies have explored its potential in drug discovery, material science, and agrochemical development, highlighting its importance in modern chemical research.

One of the most notable advancements in the study of 3,5-Dibromobenzonitrile is its role as a building block for the synthesis of kinase inhibitors. Kinases are critical targets in cancer therapy, and the ability to modulate their activity with high specificity is a major focus of current research. A 2023 study published in the Journal of Medicinal Chemistry demonstrated that derivatives of 3,5-Dibromobenzonitrile exhibit potent inhibitory effects against a subset of tyrosine kinases, suggesting their potential as lead compounds for anticancer drug development. The study utilized molecular docking and in vitro assays to validate the binding affinity and selectivity of these derivatives.

In addition to its pharmaceutical applications, 3,5-Dibromobenzonitrile has also been investigated for its utility in material science. Researchers have employed this compound as a precursor for the synthesis of organic semiconductors and liquid crystals. A recent publication in Advanced Materials (2024) reported the successful incorporation of 3,5-Dibromobenzonitrile into π-conjugated systems, resulting in materials with enhanced electronic properties. These findings open new avenues for the development of next-generation optoelectronic devices.

The environmental and safety aspects of 3,5-Dibromobenzonitrile have also been a subject of scrutiny. A 2023 toxicological study evaluated the compound's ecotoxicological profile, revealing moderate toxicity to aquatic organisms. These findings underscore the need for careful handling and disposal of this chemical in industrial and laboratory settings. Regulatory agencies are currently reviewing these data to update safety guidelines for halogenated benzonitrile derivatives.

Looking ahead, the versatility of 3,5-Dibromobenzonitrile continues to inspire innovative research. Ongoing studies are exploring its potential in agrochemicals, where it may serve as a scaffold for novel herbicides and fungicides. Furthermore, computational approaches are being leveraged to design new derivatives with improved bioactivity and reduced environmental impact. As the field progresses, 3,5-Dibromobenzonitrile is expected to remain a cornerstone in the intersection of chemical biology and pharmaceutical innovation.

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