Production Method 1

128-04-1

79-44-7

97-74-5

Reaction Conditions

1.1 Solvents: Tetrachloroethylene

Reference

Preparation of tetraalkylthiuram monosulfides

, Japan, , ,

Production Method 2

97-74-5

Reaction Conditions

Reference

Method for manufacturing tetramethylthiuram monosulfide rubber vulcanization acceleratorSynthesis of heterocyclic compounds and new routes for the preparation of certain dithiocarbonates and sulfides from potassium cyanodithioimidocarbonateTetramethylthiuram monosulfide

Ruminski, Peter G.; et al, China, 1984, 19(3), 335-44

Production Method 3

97-74-5

Reaction Conditions

1.1 16 h, rt
2.1 Solvents: Acetonitrile ;  overnight, rt

Reference

Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

Kapanda, Coco N.; et al, Journal of Medicinal Chemistry, 2009, 52(22), 7310-7314

Production Method 4

128-03-0

97-74-5

Reaction Conditions

1.1 Reagents: Iodine Solvents: Ethanol
2.1 Reagents: Potassium cyanide Solvents: Ethanol
1.1 Reagents: Sulfur monochloride Solvents: Benzene
2.1 Solvents: Benzene
3.1 Reagents: Potassium cyanide Solvents: Ethanol
1.1 Reagents: Sulfur dichloride Solvents: Benzene
2.1 Solvents: Benzene
3.1 Reagents: Potassium cyanide Solvents: Ethanol

Reference

On chalcogenolates. 185. Bis(N,N-dimethylthiocarbamoyl)sulfanesOn chalcogenolates. 185. Bis(N,N-dimethylthiocarbamoyl)sulfanesOn chalcogenolates. 185. Bis(N,N-dimethylthiocarbamoyl)sulfanes

Knoth, W.; et al Knoth, W.; et al Knoth, W.; et al, Zeitschrift fuer Anorganische und Allgemeine Chemie, 1988, (1988), 141-5

Production Method 5

79-45-8

97-74-5

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ;  45 °C; 3 h, 45 °C
2.1 Reagents: Sodium cyanide ;  45 °C → 80 °C; 2.5 h, 80 °C

Reference

Method for preparing tetramethylthiuram disulfide

, China, , ,

Production Method 6

97-74-5

540-72-7

Reaction Conditions

1.1 Reagents: Sodium nitrite ;  rt → 80 °C; 2.5 h, 80 °C

Reference

Preparation of rubber accelerator tetramethyl thiuram monosulfide and its spectral analysis

Wang, Zhen-xiang; et al, Guangpuxue Yu Guangpu Fenxi, 2015, 35(7), 1875-1878

Production Method 7

97-74-5

3878-45-3

540-72-7

Reaction Conditions

1.1 Solvents: Ethanol ,  Water ;  10 - 15 °C; 1.5 h, 15 °C → 20 °C
1.2 Reagents: Hydrogen peroxide Solvents: Water ;  15 - 20 °C; 2.5 h, 15 - 20 °C
1.3 Solvents: Water ;  15 - 20 °C; 1.5 h, 15 - 20 °C
1.4 Solvents: Ethanol ;  15 - 20 °C; 3.5 h, 15 - 20 °C

Reference

Preparation of tetraalkylthiuram monosulfide

, China, , ,

Production Method 8

97-74-5

Reaction Conditions

1.1 Reagents: Sodium cyanide ,  Ammonium chloride
1.1 Reagents: Hexaethylphosphorous triamide Solvents: Methanol ;  14 h, 23 °C
1.1 Reagents: Sodium cyanide ;  45 °C → 80 °C; 2.5 h, 80 °C

Reference

Synthesis of tetramethylthiuram monosulfideOne-Step Simultaneous Synthesis of an Industrially Important Rubber Accelerator and a Lubricant Additive by Disulfide Bond ContractionMethod for preparing tetramethylthiuram disulfide

Milosavjevic, Milutin; et al Xu, Hao-Xing; et al, Hemijska Industrija, 1992, 34(1), 193-6

Production Method 9

16420-13-6

79-45-8

97-74-5

Reaction Conditions

1.1 Solvents: Acetonitrile ;  overnight, rt

Reference

Bis(dialkylaminethiocarbonyl)disulfides as Potent and Selective Monoglyceride Lipase Inhibitors

Kapanda, Coco N.; et al, Journal of Medicinal Chemistry, 2009, 52(22), 7310-7314

Production Method 10

16420-13-6

128-04-1

97-74-5

Reaction Conditions

1.1 Solvents: Acetonitrile ;  1 - 2 h, 0 - 5 °C

Reference

Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biology

Mandalapu, Dhanaraju; et al, European Journal of Medicinal Chemistry, 2018, 143, 632-645

Production Method 11

128-04-1

97-74-5

Reaction Conditions

1.1 Reagents: Potassium ferricyanide Solvents: Water

Reference

Water-soluble dithioformate RAFT reagent and preparation method

, China, , ,

Production Method 12

97-74-5

Reaction Conditions

1.1 Reagents: Sodium hydroxide Solvents: Ethyl acetate ,  Water ;  30 min, 0 - 5 °C
2.1 Solvents: Acetonitrile ;  1 - 2 h, 0 - 5 °C
1.1 2 h, 45 °C
2.1 Reagents: Hydrogen peroxide ;  45 °C; 3 h, 45 °C
3.1 Reagents: Sodium cyanide ;  45 °C → 80 °C; 2.5 h, 80 °C

Reference

Substituted carbamothioic amine-1-carbothioic thioanhydrides as novel trichomonicidal fungicides: Design, synthesis, and biologyMethod for preparing tetramethylthiuram disulfide

Mandalapu, Dhanaraju; et al, European Journal of Medicinal Chemistry, 2018, 143, 632-645

Production Method 13

2801-10-7

97-74-5

Reaction Conditions

1.1 Solvents: Benzene
2.1 Reagents: Potassium cyanide Solvents: Ethanol

Reference

On chalcogenolates. 185. Bis(N,N-dimethylthiocarbamoyl)sulfanes

Knoth, W.; et al, Zeitschrift fuer Anorganische und Allgemeine Chemie, 1988, 556, 141-5

Production Method 14

97-91-6

97-74-5

Reaction Conditions

1.1 Solvents: Benzene
2.1 Reagents: Potassium cyanide Solvents: Ethanol

Reference

On chalcogenolates. 185. Bis(N,N-dimethylthiocarbamoyl)sulfanes

Knoth, W.; et al, Zeitschrift fuer Anorganische und Allgemeine Chemie, 1988, 556, 141-5

Production Method 15

97-74-5

597-82-0

Reaction Conditions

1.1 Solvents: Acetonitrile ;  10 h, 80 °C
1.1 Solvents: Acetonitrile ;  10 h, 80 °C
1.1 Solvents: Acetonitrile ;  1 min, 80 °C; 10 h, 80 °C

Reference

One-Step Simultaneous Synthesis of an Industrially Important Rubber Accelerator and a Lubricant Additive by Disulfide Bond ContractionOne-Step Simultaneous Synthesis of an Industrially Important Rubber Accelerator and a Lubricant Additive by Disulfide Bond ContractionGreen method for the simultaneous production of rubber accelerator tetramethylthiuram monosulfide and lubricating oil additive triphenyl thiophosphate

Xu, Hao-Xing; et al Xu, Hao-Xing; et al, Synlett, 2023, 34(1), 57-62

Production Method 16

79-45-8

97-74-5

540-72-7

Reaction Conditions

1.1 Reagents: Hydrogen peroxide Solvents: Water ;  45 °C; 3 h, 45 °C
2.1 Reagents: Sodium nitrite ;  rt → 80 °C; 2.5 h, 80 °C

Reference

Preparation of rubber accelerator tetramethyl thiuram monosulfide and its spectral analysis

Wang, Zhen-xiang; et al, Guangpuxue Yu Guangpu Fenxi, 2015, 35(7), 1875-1878

Production Method 17

97-74-5

540-72-7

Reaction Conditions

1.1 Reagents: Hydrogen peroxide ,  Polyethylene glycol mono(4-tert-octylphenyl) ether Solvents: Water ;  0.1 MPa, 40 - 45 °C; 2 h, 45 °C
2.1 Reagents: Hydrogen peroxide Solvents: Water ;  45 °C; 3 h, 45 °C
3.1 Reagents: Sodium nitrite ;  rt → 80 °C; 2.5 h, 80 °C

Reference

Preparation of rubber accelerator tetramethyl thiuram monosulfide and its spectral analysis

Wang, Zhen-xiang; et al, Guangpuxue Yu Guangpu Fenxi, 2015, 35(7), 1875-1878

Tetramethylthiuram monosulfide Raw materials

• Dimethylthyocarbamoyl cloride
• Methanethioamide,1,1'-trithiobis[N,N-dimethyl-
• Dimethyldithiocarbamic Acid Sodium Salt
• N,N-dimethylcarbamoyl chloride
• Busan 85
• Carbamodithioic acid,N,N-dimethyl-
• Methanethioamide,1,1'-tetrathiobis[N,N-dimethyl-

Tetramethylthiuram monosulfide Preparation Products

• Triphenylphosphine sulfide (3878-45-3)
• Sodium sulfocyanate (540-72-7)
• Tetramethylthiuram monosulfide (97-74-5)
• Triphenyl Phosphorothioate (597-82-0)

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• Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Sulfenyl compounds Sulfenyl compounds
• Solvents and Organic Chemicals Organic Compounds Organosulfur compounds Sulfenyl compounds

• 5437-22-9(Thiodicarbonic diamide([(H2N)C(S)]2S), N,N'-dimethyl-)
• 3735-92-0(Methyl dimethyldithiocarbamate)
• 51-82-1(Carbamodithioic acid,N,N-dimethyl-, (dimethylamino)methyl ester)
• 103110-43-6(Carbamodithioic acid, methyl(thioxomethyl)-, methyl ester)
• 332062-08-5(Fmoc-S-3-amino-4,4-diphenyl-butyric acid)
• 1270529-38-8(1,2,3,4,5,6-Hexahydro-[2,3]bipyridinyl-6-ol)
• 2680771-01-9(4-cyclopentyl-3-{(prop-2-en-1-yloxy)carbonylamino}butanoic acid)
• 2098070-20-1(2-(3-(Pyridin-3-yl)-1H-pyrazol-1-yl)acetimidamide)
• 1444113-98-7(N-(3-cyanothiolan-3-yl)-2-[(2,2,2-trifluoroethyl)sulfanyl]pyridine-4-carboxamide)
• 941977-17-9(N'-(3-chloro-2-methylphenyl)-N-2-(dimethylamino)-2-(naphthalen-1-yl)ethylethanediamide)